Aim: To examine whether incorporation of Sanoplast®, a dehydrated human acellular amniotic membrane (DHAAM),
as a topical adjunct to standard wound dressing improves healing of diabetic and venous ulcers in a real-world setting
of a single-physician practice.
Results: The area of DHAAM-treated wounds reduced to 60%, 47%, and 34% relative to their original size after the
first three applications, respectively. Thus, a 50% reduction in wound area was achieved after two applications of
DHAAM, compared to the “Standard of care” (SOC) group, which reached a 50% reduction after seven wound
dressing applications. Overall, 69% of wounds treated per protocol with Sanoplast® DHAAM completely healed
within 12 weeks of treatment compared to 47% in the SOC group. The median closure time for the DHAAM group
(9.0 weeks) was less than SOC (13.3 weeks) and the probability of wound closure increased (Hazard Ratio = 1.9; 95%
CI: 0.9–4.1).