Clinical Evidence
Rigorous, real-world data .
Driving the biologic paradigm with peer-reviewed publications and prospective clinical studies.
4×
Reduction in POAF
8.3% vs 35.2% p=0.0136
- Cardiac Surgery · Pilot Study
Epicardial Amnion-Only Patches (EAOP) in Cardiac Surgery
Postoperative atrial fibrillation (POAF) affects 20-40% of patients following CABG. Clinical evidence from a pilot study by Khalpey et al. demonstrated a profound reduction in POAF incidence with epicardial EAOP placement.
KAI-POAF Score: HC-HA/PTX3 complex-mediated M2 macrophage polarization and modulation of local inflammation.
Clinical Evidence Calculator
Bowlin et al. (2025) · Real-world wound care model
Patient Parameters
Initial Area15 cm²
Wound Age30 Days
Patient Age62 yrs
Type II Diabetes
Case Complexity
Low
TIME TO 50%
3.3 wks
vs 11.7 (SOC)
VISITS
4
vs 12 (SOC)
HEALING %
55%
vs 38% (SOC)
SAVINGS
$4,814
Per Patient Model
| Treatment | Initial | 12 Wk Proj | Reduction |
|---|---|---|---|
| Sanoplast® | 15 cm² | 5.30 cm² | 64.6% |
| SOC | 15 cm² | 9.50 cm² | 36.7% |
Clinical insight: Projections based on retrospective data (Bowlin et al., 2025). Real-world results may vary. Always combine with clinical judgment.
Library
Scientific Publications & Research
- Wound Care
- 2013
A Prospective Study of 20 Foot and Ankle Wounds Treated with Cryopreserved Amniotic Membrane and Fluid Allograft
- Werber B, Martin E. — The Journal of Foot & Ankle Surgery
A prospective investigation of 20 chronic wounds demonstrating a 90% healing rate within a 12-week observation period using cryopreserved amniotic membrane and fluid allografts.
- Sports Medicine
- 2015
Amniotic Tissues for the Treatment of Chronic Plantar Fasciosis and Achilles Tendinosis
- Werber B · Journal of Sports Medicine
Clinical evidence showing significant pain reduction (VAS score improvement from 8.2 to 2.3) in chronic heel pain cases unresponsive to standard therapies for over 6 months.
- Orthopedics
- 2021
Advocating for Peri-Articular Implantation of Biologics vs. Intra-Articular
- Werber B. · White Paper / Review
A scientific review of joint injection techniques, proposing that peri-articular infiltration provides more robust therapeutic outcomes for cartilage restoration.
- Surgical Protocols
- 1999
Critical Pathway Approach to Diabetic Pedal Infections in a Multidisciplinary Setting
- Crane M, Werber B. · The Journal of Foot & Ankle Surgery
Evaluation of clinical and financial outcomes in inpatient settings, showing a significant decrease in major amputations and hospital stay duration through established critical pathways.